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Phenotypes Associated with This Genotype
Genotype
MGI:4830774
Allelic
Composition		 Ptpn12tm1Vei/Ptpn12tm1Vei
Tg(Lck-cre)1Cwi/0
Genetic
Background		 B6.Cg-Ptpn12tm1Vei Tg(Lck-cre)1Cwi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn12tm1Vei mutation (0 available); any Ptpn12 mutation (51 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:163910 )
• much less susceptible to experimental autoimmune encephalitis induced by antibodies to Mog
• primary immune response to Mog is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory