Phenotypes Associated with This Genotype

Genotype
MGI:4830335

• Allelic Composition: Mcpt8^{tm1.1(HBEGF)Hkar}/Mcpt8^{tm1.1(HBEGF)Hkar}
• Genetic Background: B6.Cg-Mcpt8^{tm1.1(HBEGF)Hkar}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:163761 )

N • regardless of diphtheria treatment, mast cell physiology and IgE levels are normal

decreased basophil cell number ( J:163761 )

• treatment with diphtheria toxin reduces basophils in the bone marrow, spleen, and peripheral blood unlike in wild-type mice

increased susceptibility to parasitic infection ( J:163761 )

• after second infestation to ticks, diphtheria-treated mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice

hematopoietic system

decreased basophil cell number ( J:163761 )

• treatment with diphtheria toxin reduces basophils in the bone marrow, spleen, and peripheral blood unlike in wild-type mice