Mcpt8^{tm1.1(HBEGF)Hkar}
Targeted Allele Detail

Summary

• Symbol: Mcpt8^{tm1.1(HBEGF)Hkar}
• Name: mast cell protease 8; targeted mutation 1.1, Hajime Karasuyama
• MGI ID: MGI:4830320
• Synonyms: Mcpt8^DTR, Mcpt8^{tm1.1(DTR)Hkar}
• Gene: Mcpt8 Location: Chr14:56319623-56322730 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Mcpt8^{tm1.1(HBEGF)Hkar} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mcpt8^{tm1.1(HBEGF)Hkar} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A vector containing an IRES-human diphtheria toxin receptor (DTR) cDNA-EGFP and a floxed neo cassette was inserted downstream of exon 5. Cre mediated recombination removed the neo cassette. GFP expression is restricted to basophils. (J:163761)

Generation of the Mcpt8^{tm1.1(HBEGF)Hkar} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcpt8 Mutation: 26 strains or lines available

References

• Original: J:163761 Wada T, et al., Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest. 2010 Aug 2;120(8):2867-75
• All: 23 reference(s)