Phenotypes Associated with This Genotype

Genotype
MGI:4830318

• Allelic Composition: Hap1^tm2Xjl/Hap1^tm2Xjl; Tg(HCRT-cre)1Stak/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced body weight in Hap1^tm2Xjl/Hap1^tm2Xjl Tg(HCRT-cre)1Stak/0 mice

growth/size/body

decreased body weight ( J:163896 )

• the greatest differences are seen at the ages of 2?4 weeks

behavior/neurological

decreased food intake ( J:163896 )

• males and females consume 66 and 50%, respectively, of the food that control mice eat

• however, water consumption is normal

decreased locomotor activity ( J:163896 )

• show less activity than the control mice at night, with females showing a greater difference

• show less activity in response to fasting-induced metabolic stress

nervous system

abnormal hypothalamus morphology ( J:163896 )

abnormal neurite morphology ( J:163896 )

• orexin neurons of the brain display disrupted or fragmented neurites in the dorsomedial hypothalamic and lateral hypothalamic nuclei