Analysis Tools
homeostasis/metabolism
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• in mice fed a high fat diet
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• whether mice are fed a standard or high fat diet
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• during hyperinsulinemic-euglycemic clamp studies, mice fed a normal or high fat diet exhibit increased insulin-mediated suppression of hepatic glucose production compared with similarly treated wild-type mice
• however, basal hepatic glucose production is normal
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• when mice are fed a high fat diet, insulin-induced disposal of blood glucose is increased compared to in similarly treated wild-type mice
• mice fed a high fat diet exhibit greater steady-state glucose infusion rates during hyperinsulinemic-euglycemic clamp studies compared with similarly treated wild-type mice
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• mice fed a high fat diet exhibit less increase in liver triglyceride compared with similarly treated wild-type mice
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liver/biliary system
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• mice fed a high fat diet exhibit reduced morphological changes, increase in mass, and accumulation of triglycerides compared with wild-type mice
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• mice fed a high fat diet exhibit less increase in liver triglyceride compared with similarly treated wild-type mice
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• mice fed a high fat diet exhibit less increase in liver mass compared with similarly treated wild-type mice
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• in mice fed a high fat diet
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behavior/neurological
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• modestly in mice fed a high fat diet
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