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Phenotypes Associated with This Genotype
Genotype
MGI:4829793
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)4Mam/0
Genetic
Background		 involves: 129S4/SvJae * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(MMTV-cre)4Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:78415 )
• transplanted mammary epithelium exhibits more and feather-like irregular side-branches in ductal and terminal structures compared with controls
mammary gland duct hyperplasia ( J:78415 )
• transplants from virgins exhibit focal ductal hyperplasia containing papillary structure
• after one pregnancy, transplants exhibit intra-luminal focal hyperplasia

integument
abnormal branching of the mammary ductal tree ( J:78415 )
• transplanted mammary epithelium exhibits more and feather-like irregular side-branches in ductal and terminal structures compared with controls
mammary gland duct hyperplasia ( J:78415 )
• transplants from virgins exhibit focal ductal hyperplasia containing papillary structure
• after one pregnancy, transplants exhibit intra-luminal focal hyperplasia

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Cowden syndrome DOID:6457 OMIM:PS158350
 J:78415

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory