Phenotypes Associated with This Genotype

Genotype
MGI:4829788

• Allelic Composition: Foxp1^tm2.1Eem/Foxp1^tm2.1Eem; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:163662 )

cardiovascular system

abnormal heart development ( J:163662 )

• expression analysis in cardiomyocytes indicates disruption of sarcomere structure and an inhibition of cardiomyocyte maturation

double outlet right ventricle ( J:163662 )

• at E14.5

thick interventricular septum ( J:163662 )

• by E16.5

ventricular septal defect ( J:163662 )

• at E14.5 ventricular septal defects are present; however, by E16.5 most mice do not have septal defects suggesting a delay in septal development

thick ventricular wall ( J:163662 )

• by E16.5 both the right and left ventricle walls are thicker compared to controls

increased fetal cardiomyocyte proliferation ( J:163662 )

• increased proliferation that is most prominent in the trabecular layer at E14.5 and E16.5

muscle

increased fetal cardiomyocyte proliferation ( J:163662 )

• increased proliferation that is most prominent in the trabecular layer at E14.5 and E16.5

abnormal sarcomere morphology ( J:163662 )

• expression analysis in cardiomyocytes indicates disruption of sarcomere structure

cellular

increased fetal cardiomyocyte proliferation ( J:163662 )

• increased proliferation that is most prominent in the trabecular layer at E14.5 and E16.5