Phenotypes Associated with This Genotype

Genotype
MGI:4822129

• Allelic Composition: Bmal1^tm2Bra/Bmal1^tm2Bra; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:155089 )

• in the rest and active phases

cardiovascular system

increased heart rate ( J:155089 )

• in the rest and active phases

decreased mean systemic arterial blood pressure ( J:155089 )

• within the active phase

homeostasis/metabolism

abnormal protein level ( J:155089 )

• mice fail to exhibit circadian alterations in total plasma tissue plasminogen activator (tPA) levels unlike similarly treated wild-type mice

• however, circadian alteration in plasminogen activator inhibitor-1 (PAI-1) levels is normal

abnormal response to injury ( J:155089 )

• time to thrombotic vascular occlusion (TTVO) subsequent to photochemical injury is decreased at zeitgeber time (ZT) 14 unlike in similarly treated wild-type mice