Phenotypes Associated with This Genotype

Genotype
MGI:4821420

• Allelic Composition: Cd1d1^tm1Luc/Cd1d1^tm1Luc; Ldlr^tm1Her/Ldlr^tm1Her
• Genetic Background: B6.129S-Cd1d1^tm1Luc Ldlr^tm1Her

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:110061 )

increased susceptibility to atherosclerosis ( J:110061 )

• male mice after 4 weeks on the Western diet have lesions of small fatty streaks on the aorta were 40.4% smaller than Ldlr^tm1Her

• Oil red O stained serial sections of 4-week-old mice fed a western diet, revealed had 31.7% less lipid staining than Ldlr^tm1Her

homeostasis/metabolism

decreased circulating VLDL cholesterol level ( J:110061 )

• slightly lower levels of very low density lipoprotein