Phenotypes Associated with This Genotype

Genotype
MGI:4821160

• Allelic Composition: F2rl1^tm1Bpd/F2rl1^tm1Bpd; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: B6.Cg-F2rl1^tm1Bpd Tg(MMTV-PyVT)634Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal tumor vascularization ( J:138924 )

• mutants show a delayed angiogenic switch in breast tumors, with decreased vessel infiltration in and around tumors compared to Tg(MMTV-PyVT)634Mul mice

neoplasm

abnormal tumor vascularization ( J:138924 )

• mutants show a delayed angiogenic switch in breast tumors, with decreased vessel infiltration in and around tumors compared to Tg(MMTV-PyVT)634Mul mice

decreased mammary gland tumor incidence ( J:138924 )

• adenomas and mammary adenocarcinoma develop slower in mutants than in Tg(MMTV-PyVT)634Mul mice resulting in reduced metastasis

increased mammary adenocarcinoma incidence ( J:138924 )

• delay in the appearance of palpable tumors and progression of mammary adenocarcinoma compared Tg(MMTV-PyVT)634Mul mice

increased adenoma incidence ( J:138924 )

• adenomas develop at a slower rate in mutants than in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:138924 )

• adenomas and mammary adenocarcinoma develop slower in mutants than in Tg(MMTV-PyVT)634Mul mice resulting in reduced metastasis

increased mammary adenocarcinoma incidence ( J:138924 )

• delay in the appearance of palpable tumors and progression of mammary adenocarcinoma compared Tg(MMTV-PyVT)634Mul mice

integument

decreased mammary gland tumor incidence ( J:138924 )

• adenomas and mammary adenocarcinoma develop slower in mutants than in Tg(MMTV-PyVT)634Mul mice resulting in reduced metastasis

increased mammary adenocarcinoma incidence ( J:138924 )

• delay in the appearance of palpable tumors and progression of mammary adenocarcinoma compared Tg(MMTV-PyVT)634Mul mice