Phenotypes Associated with This Genotype

Genotype
MGI:4820985

• Allelic Composition: Cckbr^tm1Tom/Cckbr^tm1Tom
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to cocaine ( J:107970 )

• cocaine-treated mice exhibit decreased activity compared with similarly treated wild-type mice

enhanced behavioral response to addictive substance ( J:107970 )

• amphetamine-treated mice exhibit increased activity compared with similarly treated wild-type mice

enhanced behavioral response to morphine ( J:107970 )

• morphine-treated mice exhibit increased activity compared with similarly treated wild-type mice

hyperactivity ( J:107970 )

• however, treatment with a dopamine receptor 1 antagonist had no effect on activity levels

• mice exhibit increased activity compared with wild-type mice

• treatment with the dopamine receptor 2 selective antagonist reduce activity unlike in similarly treated wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:107970 )

• treatment with the dopamine receptor 2 selective antagonist reduce activity unlike in similarly treated wild-type mice

• however, treatment with a dopamine receptor 1 antagonist had no effect on activity levels