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Phenotypes Associated with This Genotype
Genotype
MGI:4820811
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh/Gt(ROSA)26Sor+
Scgb1a1tm1(cre/ERT)Blh/Scgb1a1+
Genetic
Background		 involves: 129S6/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh mutation (0 available); any Gt(ROSA)26Sor mutation (1095 available)
Scgb1a1tm1(cre/ERT)Blh mutation (1 available); any Scgb1a1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
bronchial epithelial hyperplasia ( J:161806 )
• after 13 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice
• however, areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment

neoplasm
neoplasm ( J:161806 )
N
• areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory