Phenotypes Associated with This Genotype

Genotype
MGI:4820735

• Allelic Composition: Psmg1^tm1.1Smta/Psmg1^tm1.1Smta; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:162790 )

• mice die by P21

nervous system

decreased cerebellar granule cell precursor proliferation ( J:162790 )

abnormal cerebral hemisphere morphology ( J:162790 )

• as early as P3, cerebrum weight is decreased compared to in wild-type mice

• however, the formation of pyramidal cell and granular cell layers is normal

decreased dentate gyrus size ( J:162790 )

• reduced

small hippocampus ( J:162790 )

thin cerebral cortex ( J:162790 )

abnormal cerebellum morphology ( J:162790 )

• as early as P3, cerebellum weight is decreased compared to in wild-type mice

abnormal cerebellum development ( J:162790 )

• mice lack the normal three layers observed in wild-type mice

behavior/neurological

limb grasping ( J:162790 )

tremors ( J:162790 )

ataxia ( J:162790 )

growth/size/body

postnatal growth retardation ( J:162790 )

cellular

decreased cerebellar granule cell precursor proliferation ( J:162790 )