Phenotypes Associated with This Genotype

Genotype
MGI:4820588

• Allelic Composition: Apc^Min/Apc⁺; Pms2^tm1Lisk/Pms2^tm1Lisk
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:46419 )

• mice die earlier than Apc^min heterozygotes

neoplasm

increased intestinal adenoma incidence ( J:46419 )

• mice develop 2.3 times more adenomatous polyps in the intestine compared with Apc^min heterozygotes

• however, no evidence of adenocarcinoma is observed

• tumors exhibit microsatellite instability

digestive/alimentary system

increased intestinal adenoma incidence ( J:46419 )

• mice develop 2.3 times more adenomatous polyps in the intestine compared with Apc^min heterozygotes

• however, no evidence of adenocarcinoma is observed

• tumors exhibit microsatellite instability

intestine polyps ( J:46419 )

• mice develop 2.3 times more adenomatous polyps in the intestine compared with Apc^min heterozygotes