Phenotypes for Apc Pms2 MGI:4820588 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^Min/Apc⁺ Pms2^tm1Lisk/Pms2^tm1Lisk
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (156 available)
Pms2^tm1Lisk mutation (1 available); any Pms2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:46419 )

• mice die earlier than Apc^min heterozygotes

neoplasm

increased intestinal adenoma incidence ( J:46419 )

• mice develop 2.3 times more adenomatous polyps in the intestine compared with Apc^min heterozygotes

• however, no evidence of adenocarcinoma is observed

• tumors exhibit microsatellite instability

digestive/alimentary system

increased intestinal adenoma incidence ( J:46419 )

• mice develop 2.3 times more adenomatous polyps in the intestine compared with Apc^min heterozygotes

• however, no evidence of adenocarcinoma is observed

• tumors exhibit microsatellite instability

intestine polyps ( J:46419 )

• mice develop 2.3 times more adenomatous polyps in the intestine compared with Apc^min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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