Phenotypes Associated with This Genotype

Genotype
MGI:4820573

• Allelic Composition: Ptk2^tm1.1Guan/Ptk2^tm1.1Guan; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:162690 )

• fewer mutant embryos than Mendelian ratio at E13.5

• no live mutant embryos at E14.5

cellular

increased apoptosis ( J:162690 )

• increased apoptosis in the liver, brain, placenta and skin at E13.5

• presence of apoptotic endothelial cells (ECs) in the blood vessel of the brain and skin

• increased apoptosis after recombinant adenoviruses encoding Cre (Ad-Cre) infection of the ECs in vitro

growth/size/body

decreased embryo size ( J:162690 )

• at E14.5 and E15.5

embryo

abnormal placenta vasculature ( J:162690 )

• lack of vessels containing nucleated red blood cells in placenta at E13.5

abnormal vitelline vasculature morphology ( J:162690 )

• reduced vascular network in mutant yolk sac at E13.5

decreased embryo size ( J:162690 )

• at E14.5 and E15.5

thin placenta labyrinth ( J:162690 )

• decrease in the thickness of the labyrinth layer of the placenta at E13.5

cardiovascular system

abnormal blood vessel morphology ( J:162690 )

• fewer blood vessels in the brain, spinal cord and skin at E13.5

abnormal placenta vasculature ( J:162690 )

• lack of vessels containing nucleated red blood cells in placenta at E13.5

abnormal vitelline vasculature morphology ( J:162690 )

• reduced vascular network in mutant yolk sac at E13.5

dilated vasculature ( J:162690 )

• dilation of vessels in the brain, spinal cord and skin at E12.5

hemorrhage ( J:162690 )

• perivascular hemorrhages at E13.5

increased vascular permeability ( J:162690 )

• increased permeability after Ad-Cre infection of ECs in vitro

homeostasis/metabolism

edema ( J:162690 )

• at E13.5