Phenotypes for Mapk1 Mapk3 MGI:4820403 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mapk1^tm2Melo/Mapk1^tm2Melo Mapk3^tm1Gpg/Mapk3^tm1Gpg
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm2Melo mutation (0 available); any Mapk1 mutation (42 available)
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitosis ( J:162580 )

• more mouse embryonic fibroblasts (MEF) exposed to a cre-expressing retroviral vector are in G0/G1 phase and fewer in S phase than MEF not exposed to cre

increased fibroblast apoptosis ( J:162580 )

• in mouse embryonic fibroblasts exposed to a cre-expressing retroviral vector

early cellular replicative senescence ( J:162580 )

• mouse embryonic fibroblasts (MEFs) exposed to a cre-expressing retroviral vector exhibit increased senescence compared with MEFs not exposed to cre

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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