Mapk1^tm2Melo
Targeted Allele Detail

Summary

• Symbol: Mapk1^tm2Melo
• Name: mitogen-activated protein kinase 1; targeted mutation 2, Sylvain Meloche
• MGI ID: MGI:4820400
• Synonyms: Erk2^flox
• Gene: Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
• Alliance: Mapk1^tm2Melo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162580
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and left exon 3 floxed. (J:232897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk1 Mutation: 42 strains or lines available

References

• Original: J:162580 Voisin L, et al., Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol Cell Biol. 2010 Jun;30(12):2918-32
• All: 7 reference(s)