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Phenotypes Associated with This Genotype
Genotype
MGI:4819951
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/?
Tg(tetO-MAPT*P301L)#Kha/?
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (7 available)
Tg(tetO-MAPT*P301L)#Kha mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• a significant loss in brain weight by 5.5 months
• when treated with doxycycline during 5.5 to 10 months, the loss of brain weight was significantly protected
• significant decrease in total numbers of CA1 hippocampal neurons
• CA1 neuron estimates were stabilized after brief (6- to 8-week) doxycycline treatment
• gross atrophy of the forebrain was evident in a 10-month-old mouse
• develop argyrophilic tangle-like inclusions in the cortex by 4 months and in the hippocampal formation by 5.5 months
• when treated with doxycycline at 2.5 month, the tau pathology ceased to progress
• when treated with doxycycline at 2.5 month, the tau pathology ceased to progress
• the neuronal inclusions composed of a mass of straight tau filaments
• approximately 23% of CA1 pyramidal cells remaining at 8.5 months
• CA1 neuron estimates were stabilized after brief (6- to 8-week) doxycycline treatment

behavior/neurological
• he retention of spatial memory examined by the Morris water maze were impaired as the mice aged
• deficit in spatial navigation was also seen in younger mice
• the performance improved when treated with doxycycline at 2.5 month-old or at 5.5 month-old

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:99626


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory