Phenotypes Associated with This Genotype

Genotype
MGI:4819236

• Allelic Composition: Tg(HRAS)2Jic/?
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:73016 )

• 77 week survival rate for males is 53% and for females is 32%

limbs/digits/tail

abnormal limb muscle morphology ( J:135606 )

• skeletal myopathy in femoral muscle

• heart tongue and esophagus muscles are normal

growth/size/body

decreased body weight ( J:135606 )

• body weights up to 36 weeks of age are between 80 and 100% of controls

neoplasm

neoplasm ( J:64968 )

N • no tumors or pre-neoplasias among F2 mice within the first 6 months

abnormal tumor morphology ( J:64968 )

• point mutations often found in transgene in cells from tumors

increased tumor incidence ( J:64968 )

• 24/50 F2 mice develop tumors within 18 months

• 6/24 F2 mice that developed tumors developed double tumors

increased incidence of tumors by chemical induction ( J:73016 , J:101590 )

• N-methyl-N-nitrosourea (MNU) induced tumors involve point mutations in transgene while ENU induced tumors do not (J:73016)

• transgene overexpression in tumors induced by MNU, ENU, and urethane (J:73016)

• incidence of chemically induced lung adenomas and hyperplasia is higher than in controls (J:101590)

• chemical induction of papillomas and squamous cell carcinomas of the forestomach are common (J:101590)

• chemically induced hemangiosarcomas of the esophagus and small intestine are common (J:101590)

increased classified tumor incidence ( J:64968 )

increased skin papilloma incidence ( J:64968 )

• one example within 3 months

• 3 skin papillomas in 50 F2 mice

increased lymphoma incidence ( J:64968 )

• 2 lymphomas in 50 F2 mice

increased adenocarcinoma incidence ( J:64968 )

• 4 harderian gland adenocarcinomas in 50 F2 mice

increased lung adenocarcinoma incidence ( J:64968 )

• 8 lung adenocarcinomas in 50 F2 mice

increased sarcoma incidence ( J:64968 )

• founder and 2 of 20 F1 mice develop angiosarcoma within 5 months

• 13 angiosarcomas in 50 F2 mice

respiratory system

increased lung adenocarcinoma incidence ( J:64968 )

• 8 lung adenocarcinomas in 50 F2 mice

muscle

abnormal skeletal muscle morphology ( J:99371 )

• myopathic changes seen at 10-13 weeks in biceps femoris, gastrocnemius, and triceps brachii

• increased cell density occasionally

• diaphragm and soleus are normal

abnormal limb muscle morphology ( J:135606 )

• skeletal myopathy in femoral muscle

• heart tongue and esophagus muscles are normal

abnormal skeletal muscle fiber morphology ( J:99371 )

• biceps femoris is most susceptible to myopathic changes

• internal architecture of muscle fibers becomes disorganized

increased variability of skeletal muscle fiber size ( J:99371 )

centrally nucleated skeletal muscle fibers ( J:99371 )

skeletal muscle fiber degeneration ( J:99371 , J:135606 )

• scattered (J:99371)

• some hyaline degeneration of muscle fibers observed (J:135606)

skeletal muscle fiber necrosis ( J:99371 )

• scattered

abnormal pectoral muscle morphology ( J:135606 )

• skeletal myopathy

skeletal muscle interstitial fibrosis ( J:135606 )

• some increase in interstitial collagen fibers

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:73016 , J:101590 )

• N-methyl-N-nitrosourea (MNU) induced tumors involve point mutations in transgene while ENU induced tumors do not (J:73016)

• transgene overexpression in tumors induced by MNU, ENU, and urethane (J:73016)

• incidence of chemically induced lung adenomas and hyperplasia is higher than in controls (J:101590)

• chemical induction of papillomas and squamous cell carcinomas of the forestomach are common (J:101590)

• chemically induced hemangiosarcomas of the esophagus and small intestine are common (J:101590)

integument

increased skin papilloma incidence ( J:64968 )

• one example within 3 months

• 3 skin papillomas in 50 F2 mice