Phenotypes Associated with This Genotype

Genotype
MGI:4819194

• Allelic Composition: Brca2^tm1Brn/Brca2^tm1Brn; Trp53^tm1Brn/Trp53⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

High-grade prostate intraepithelial neoplasia in Brca2^tm1Brn/Brca2^tm1Brn Tg(Pbsn-cre)4Prb/0 Trp53^tm1Brn/Trp53^tm1Brn and prostate hyperplasia and intraepithelial neoplasia in Brca2^tm1Brn/Brca2^tm1Brn Trp53^tm1Brn/Trp53⁺ Tg(Pbsn-cre)4Prb/0 mice

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:161511 )

♂ • focal low grade PIN are seen at 10 - 14 months of age

♂ • by 15 - 20 months of age both focal low grade and high grade PIN are seen

♂ • the incidence of high grade PIN is increased in mutant mice homozygous for the Trp53 allele relative to mice heterozygous for the Trp53 allele

♂ • levels of cell proliferation are 9 fold higher in PIN lesions

reproductive system

abnormal prostate gland morphology ( J:161511 )

♂ • focal hyperplasia is seen beginning at 10 -14 months of age

increased prostate intraepithelial neoplasia incidence ( J:161511 )

♂ • focal low grade PIN are seen at 10 - 14 months of age

♂ • by 15 - 20 months of age both focal low grade and high grade PIN are seen

♂ • the incidence of high grade PIN is increased in mutant mice homozygous for the Trp53 allele relative to mice heterozygous for the Trp53 allele

♂ • levels of cell proliferation are 9 fold higher in PIN lesions

abnormal prostate gland physiology ( J:161511 )

♂ • areas of hyperplasia are positive for markers of DNA damage

♂ • 4 fold increase in apoptotic cells in PIN foci

endocrine/exocrine glands

abnormal prostate gland morphology ( J:161511 )

♂ • focal hyperplasia is seen beginning at 10 -14 months of age

increased prostate intraepithelial neoplasia incidence ( J:161511 )

♂ • focal low grade PIN are seen at 10 - 14 months of age

♂ • by 15 - 20 months of age both focal low grade and high grade PIN are seen

♂ • the incidence of high grade PIN is increased in mutant mice homozygous for the Trp53 allele relative to mice heterozygous for the Trp53 allele

♂ • levels of cell proliferation are 9 fold higher in PIN lesions

abnormal prostate gland physiology ( J:161511 )

♂ • areas of hyperplasia are positive for markers of DNA damage

♂ • 4 fold increase in apoptotic cells in PIN foci