Phenotypes for Brca2 Tg(Pbsn-cre)4Prb MGI:4819192 MGI Mouse

neoplasm

• focal low grade PIN are seen in the lumen at 15 - 20 months of age

• low grade PIN lesions form characteristic tufting and cribiform patterns

• hyperplasia and low grade PIN are seen all 4 lobes

reproductive system

prostate gland hyperplasia ( J:161511 )

• focal hyperplasia containing atypical cells is seen beginning at 10 -14 months of age

• hyperplasia and low grade PIN are seen all 4 lobes

• focal low grade PIN are seen in the lumen at 15 - 20 months of age

• low grade PIN lesions form characteristic tufting and cribiform patterns

• hyperplasia and low grade PIN are seen all 4 lobes

• areas of hyperplasia are positive for markers of DNA damage

• 3 fold increase in apoptotic cells in areas of hyperplasia and low grade PIN

endocrine/exocrine glands

prostate gland hyperplasia ( J:161511 )

• focal hyperplasia containing atypical cells is seen beginning at 10 -14 months of age

• hyperplasia and low grade PIN are seen all 4 lobes

• focal low grade PIN are seen in the lumen at 15 - 20 months of age

• low grade PIN lesions form characteristic tufting and cribiform patterns

• hyperplasia and low grade PIN are seen all 4 lobes

• areas of hyperplasia are positive for markers of DNA damage

• 3 fold increase in apoptotic cells in areas of hyperplasia and low grade PIN

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24