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Phenotypes Associated with This Genotype
Genotype
MGI:4819097
Allelic
Composition
Chrdtm1Emdr/Chrdtm1Emdr
Nodaltm1Rob/Nodal+
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrdtm1Emdr mutation (1 available); any Chrd mutation (18 available)
Nodaltm1Rob mutation (3 available); any Nodal mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in 14 of 19 mice with defects in anterior midline tissues

embryo
• expression analysis indicates defects in patterning and function in the anterior most axial mesendoderm
• 23% (19 of 83) show defects in anterior midline tissues
• 14 of these 19 show holoprosencephaly in association with anterior body truncation and fused first pharyngeal arches
• fused in 14 of 19 mice with defects in anterior midline tissues
• expression analysis indicates impairment in ADE specification
• expression analysis indicates defects in patterning and function

cardiovascular system
• cardiac laterality defects are seen in 5 mice

craniofacial
• fused in 14 of 19 mice with defects in anterior midline tissues


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory