Mouse Genome Informatics
cx
    Chrdtm1Emdr/Chrdtm1Emdr
Nodaltm1Rob/Nodal+

involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• in 14 of 19 mice with defects in anterior midline tissues

embryogenesis
• expression analysis indicates defects in patterning and function
• 23% (19 of 83) show defects in anterior midline tissues
• 14 of these 19 show holoprosencephaly in association with anterior body truncation and fused first pharyngeal arches
• fused in 14 of 19 mice with defects in anterior midline tissues
• expression analysis indicates defects in patterning and function in the anterior most axial mesendoderm
• expression analysis indicates impairment in ADE specification

cardiovascular system
• cardiac laterality defects are seen in 5 mice

craniofacial
• fused in 14 of 19 mice with defects in anterior midline tissues

Mouse Models of Human Disease
OMIM IDRef(s)
Holoprosencephaly 236100 J:161524