Phenotypes Associated with This Genotype

Genotype
MGI:4819009

• Allelic Composition: Pms2^tm1.1Wed/Pms2^tm1.1Wed
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:162378 )

• in 4 of 24 mice

mortality/aging

premature death ( J:162378 )

• median survival is 12 months

neoplasm

increased liver adenoma incidence ( J:162378 )

• hepatic adenomas in 2 of 29 mice

increased hemangioma incidence ( J:162378 )

• in 1 of 29 mice

increased lymphoma incidence ( J:162378 )

• seen in 90% (26/29) of mice

increased T cell derived lymphoma incidence ( J:162378 )

• in 4 of 24 mice

increased B cell derived lymphoma incidence ( J:162378 )

• seen in 83% (20/24) of mice

increased adenocarcinoma incidence ( J:162378 )

• uterine adenocarcinoma in 1 of 29 mice

increased sarcoma incidence ( J:162378 )

• in 5 of 29 mice

liver/biliary system

increased liver adenoma incidence ( J:162378 )

• hepatic adenomas in 2 of 29 mice

cellular

abnormal DNA repair ( J:162378 )

• increase in microsatellite instability and mutation frequencies

abnormal mismatch repair ( J:162378 )

• absence of MMR in MEFs

immune system

abnormal class switch recombination ( J:162378 )

• decrease in ex vivo class switch recombination

reproductive system

reproductive system phenotype ( J:162378 )

N • in contrast to homozygous null males, males are fertile with normal spermatogenesis and normal testis size

hematopoietic system

abnormal class switch recombination ( J:162378 )

• decrease in ex vivo class switch recombination

homeostasis/metabolism

abnormal DNA repair ( J:162378 )

• increase in microsatellite instability and mutation frequencies

abnormal mismatch repair ( J:162378 )

• absence of MMR in MEFs