About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4819009
Allelic
Composition
Pms2tm1.1Wed/Pms2tm1.1Wed
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pms2tm1.1Wed mutation (0 available); any Pms2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

mortality/aging
• median survival is 12 months

neoplasm
• hepatic adenomas in 2 of 29 mice
• in 1 of 29 mice
• seen in 90% (26/29) of mice
• seen in 83% (20/24) of mice
• uterine adenocarcinoma in 1 of 29 mice
• in 5 of 29 mice

liver/biliary system
• hepatic adenomas in 2 of 29 mice

cellular
• increase in microsatellite instability and mutation frequencies
• absence of MMR in MEFs

immune system
• decrease in ex vivo class switch recombination

reproductive system
N
• in contrast to homozygous null males, males are fertile with normal spermatogenesis and normal testis size

hematopoietic system
• decrease in ex vivo class switch recombination

homeostasis/metabolism
• increase in microsatellite instability and mutation frequencies
• absence of MMR in MEFs


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/13/2019
MGI 6.14
The Jackson Laboratory