Phenotypes Associated with This Genotype

Genotype
MGI:4818917

• Allelic Composition: Slc2a2^tm1Thor/Slc2a2^tm1Thor; Tg(Ins1-SLC2A1)1Thor/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:162050 )

N • expression of transgene prevents early lethality observed in Slc2a2^tm1Thor homozygous non-transgenic mice

growth/size/body

growth/size/body region phenotype ( J:162050 )

N • body weight and composition are identical to wild-type controls at 12-16 weeks

homeostasis/metabolism

impaired adaptive thermogenesis ( J:162050 )

• during 24 h of food deprivation, body temperature decreases significantly compared to wild-type controls at end of dark period as mice enter torpor

• when exposed continuously to low temperature (4 degrees C), mutants show reduced ability to regulate and maintain body temperature compared to controls

• when mice are deprived of food for 6 h and receive intracerebroventricular injections of 2-deoxyglucose (0.5 mg, 1.5 mg or 2.5 mg), no significant decrease in body temperature is observed compared to wild-type controls at the lowest dose after 2 hours; at the median dose, a significant difference is seen at 2 hours but is less significant than controls; at the highest dose, temperature decrease is similar to that observed in controls

behavior/neurological

decreased locomotor activity ( J:162050 )

• at end of dark period, mutants show less locomotor acitivity compared to controls as they enter torpor during 24 h of food deprivation

• when exposed continuously to low temperature (4 degrees C), mutants and wild-type controls display similar locomotor activity