Phenotypes Associated with This Genotype

Genotype
MGI:4818456

• Allelic Composition: Hbegf^tm1.1Mek/Hbegf^tm1.1Mek
• Genetic Background: B6.Cg-Hbegf^tm1.1Mek

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal atrioventricular valve morphology ( J:161948 )

• atrioventricular valve thickness is increased compared to in wild-type mice

abnormal heart ventricle outflow tract morphology ( J:161948 )

• outflow tract valve thickness is increased compared to in wild-type mice

abnormal cardiovascular system physiology ( J:161948 )

• mesenchyme cells from cushion explants exhibit increased proliferation compared with similarly treated wild-type explants

• proliferation of outflow tract (OFT) and atrioventricular (AV) valve mesenchyme in culture is increased compared to in wild-type mice

• however, in vivo proliferation of endocardium, proliferation of endocardial cell from cushion explants, and apoptosis of OFT and AV endocardium and mesenchyme are normal