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Phenotypes Associated with This Genotype
Genotype
MGI:4462851
Allelic
Composition		 Ssbp2tm1Lana/Ssbp2tm1Lana
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssbp2tm1Lana mutation (0 available); any Ssbp2 mutation (38 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:162035 )
• median survival is 122 days instead of 182 days for Trp53tm1Tyj homozygotes

neoplasm
increased T cell derived lymphoma incidence ( J:162035 )
• mice exhibit a 2.4-fold increase in thymic lymphomas compared with Trp53tm1Tyj homozygotes
• thymic lymphomas are more aggressive than in Trp53tm1Tyj homozygotes

immune system
thymus hypoplasia ( J:162035 )
• at 3 and 6 months

hematopoietic system
thymus hypoplasia ( J:162035 )
• at 3 and 6 months

endocrine/exocrine glands
thymus hypoplasia ( J:162035 )
• at 3 and 6 months
increased T cell derived lymphoma incidence ( J:162035 )
• mice exhibit a 2.4-fold increase in thymic lymphomas compared with Trp53tm1Tyj homozygotes
• thymic lymphomas are more aggressive than in Trp53tm1Tyj homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory