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Phenotypes Associated with This Genotype
Genotype
MGI:4461138
Allelic
Composition
Tg(Gfap-TNF*)K21Gkl/0
Tnfrsf1atm1Blt/Tnfrsf1a+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TNF*)K21Gkl mutation (1 available)
Tnfrsf1atm1Blt mutation (5 available); any Tnfrsf1a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• neurological symptoms by the sixth month of age, delayed compared to Tg alone
• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:106592


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory