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Phenotypes Associated with This Genotype
Genotype
MGI:4461137
Allelic
Composition
Tg(Gfap-TNF*)K21Gkl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TNF*)K21Gkl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• a progressive accumulation of inflammatory cells at one week of age

nervous system
• oligodendrocyte apoptosis starting at 2 weeks of age
• a progressive accumulation of inflammatory cells at one week of age
• at 4 weeks of age myelin loss is accompanied by astrocyte loss
• widespread astrocytic gliosis starting at one week of age
• blood-brain barrier damage at the meninges of the spinal cord starting at one week of age
• at 4 weeks of age myelin loss is accompanied by axonal damage
• by fourth week of age, demyelinating lesions cover 30% of the original myelin mass

cellular
• oligodendrocyte apoptosis starting at 2 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:126200
OMIM:612594
OMIM:612595
OMIM:612596
OMIM:614810
J:106592


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory