Phenotypes Associated with This Genotype

Genotype
MGI:4461137

• Allelic Composition: Tg(Gfap-TNF*)K21Gkl/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

CNS inflammation ( J:106592 )

• a progressive accumulation of inflammatory cells at one week of age

nervous system

abnormal oligodendrocyte apoptosis ( J:106592 )

• oligodendrocyte apoptosis starting at 2 weeks of age

CNS inflammation ( J:106592 )

• a progressive accumulation of inflammatory cells at one week of age

abnormal astrocyte morphology ( J:106592 )

• at 4 weeks of age myelin loss is accompanied by astrocyte loss

astrocytosis ( J:106592 )

• widespread astrocytic gliosis starting at one week of age

abnormal meninges morphology ( J:106592 )

• blood-brain barrier damage at the meninges of the spinal cord starting at one week of age

axon degeneration ( J:106592 )

• at 4 weeks of age myelin loss is accompanied by axonal damage

demyelination ( J:106592 )

• by fourth week of age, demyelinating lesions cover 30% of the original myelin mass

cellular

abnormal oligodendrocyte apoptosis ( J:106592 )

• oligodendrocyte apoptosis starting at 2 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:106592