Mouse Genome Informatics
cx
    Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0

involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• disease started between 7 and 10 weeks of age, with classical paralytic EAE signs

immune system
• between 15% and 20% of mice develop spontaneous EAE
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues

muscle
• in a minority of cases, with a spastic component

nervous system
• inflammatory infiltrates in the trigeminal ganglia, spinal ganglia, spinal roots despite the absence of MOG within these tissues
• inflammatory infiltrates in the peripheral nervous system despite the absence of MOG within these tissues
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in the spinal cord
• within the spinal cord and optic nerve

vision/eye
• lesions consisting of lymphocytic infiltration, demyelation and axonal damage in optic nerve

Mouse Models of Human Disease
OMIM IDRef(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:151335