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Phenotypes Associated with This Genotype
Genotype
MGI:4460905
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Gt(ROSA)26Sortm1(ITK/SYK)Jrld mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Enlarged spleen and solid organ infiltration with abnormally proliferating T cells in Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mice

mortality/aging
premature death ( J:160931 )
• mice develop lethal wasting and die by 60 weeks of age unlike wild-type mice

immune system
enlarged spleen ( J:160931 )
• at 50 weeks
abnormal T cell activation ( J:160931 )
• lymphomas consists of enlarged, activated, and highly proliferative T cells
increased T cell proliferation ( J:160931 )
• lymphomas consists of enlarged, activated, and highly proliferative T cells

neoplasm
increased T cell derived lymphoma incidence ( J:160931 )
• mice develop infiltrating lymphocytes into multiple organs unlike in wild-type mice
• lymphomas consists of enlarged, activated, and highly proliferative T cells

growth/size/body
cachexia ( J:160931 )
• mice develop lethal wasting unlike wild-type mice
enlarged spleen ( J:160931 )
• at 50 weeks

hematopoietic system
enlarged spleen ( J:160931 )
• at 50 weeks
abnormal T cell activation ( J:160931 )
• lymphomas consists of enlarged, activated, and highly proliferative T cells
increased T cell proliferation ( J:160931 )
• lymphomas consists of enlarged, activated, and highly proliferative T cells

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:160931 )
• mice develop infiltrating lymphocytes into multiple organs unlike in wild-type mice
• lymphomas consists of enlarged, activated, and highly proliferative T cells

cellular
increased T cell proliferation ( J:160931 )
• lymphomas consists of enlarged, activated, and highly proliferative T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory