Phenotypes Associated with This Genotype

Genotype
MGI:4460235

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Il10^tm1Cgn/Il10^tm1Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:105858 )

• lesion development substantially increased at 16 weeks relative to Apoe^tm1Unc alone

• lesion size about 10 fold greater at 48 weeks than at 16 weeks but similar to controls

homeostasis/metabolism

abnormal circulating cholesterol level ( J:105858 )

increased circulating LDL cholesterol level ( J:105858 )

• shift in cholesterol from VLDL to LDL

decreased circulating VLDL cholesterol level ( J:105858 )

• shift in cholesterol from VLDL to LDL

abnormal circulating cytokine level ( J:105858 )

increased circulating interferon-gamma level ( J:105858 )

• at 48 weeks

increased circulating interleukin-12 level ( J:105858 )

• elevated at both 16 and 48 weeks

abnormal blood coagulation ( J:105858 )

• increased thrombin formation

• enhanced thrombotic response to injected thrombin

abnormal arterial thrombosis ( J:105858 )

• intracoronary platelet thrombi are significantly more frequent

immune system

abnormal circulating cytokine level ( J:105858 )

increased circulating interferon-gamma level ( J:105858 )

• at 48 weeks

increased circulating interleukin-12 level ( J:105858 )

• elevated at both 16 and 48 weeks