Phenotypes Associated with This Genotype

Genotype
MGI:4460231

• Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:59872 )

• mice older than 4 weeks weigh significantly less than controls

digestive/alimentary system

abnormal intestine physiology ( J:59872 )

• increased colon permeability to mannitol at 2, 4, and 10weeks but not under germ free conditions

• ileal permeability to mannitol 3X higher than in controls at 2 weeks but normal at 6 weeks

• more IFNgamma and TNFalpha produced in the ileum and colon than in controls

• colonic iNOS production increases with age after 4 weeks

colitis ( J:59872 )

• mild colitis at 4 weeks which plateaus by 8 weeks

• no ileal injury through 16 weeks

• no colitis when raised in germ free conditions

immune system

colitis ( J:59872 )

• mild colitis at 4 weeks which plateaus by 8 weeks

• no ileal injury through 16 weeks

• no colitis when raised in germ free conditions