Phenotypes Associated with This Genotype

Genotype
MGI:4459734

• Allelic Composition: Batf^tm1.1Ejt/Batf^tm1.1Ejt
• Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Low IgG1 and IgG2c levels in spleen and absence of germinal centers in sRBC-immunized Batf^tm1.1Ejt/Batf^tm1.1Ejt mice

hematopoietic system

abnormal class switch recombination ( J:160935 )

• unlike control cells which when stimulated with LPS and IL-4 decreased IgM production and began IgG1, and IgE production, these cells continue to produce IgM

abnormal T-helper 2 cell differentiation ( J:160935 )

• when spenocytes are cultured under Th2 polarization conditions QPCR of Gata3 and Il4 show defects in polarization

absent germinal center B cells ( J:160935 )

• absent PNA+ cells

decreased CD4-positive, alpha-beta T cell number ( J:160935 )

• in spleen and peyers patch

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:160935 )

• small but significant reduction in Treg cells

decreased T follicular helper cell number ( J:160935 )

• memory-type CD62L-CXCR5+ Tfh cells are reduced by 70% in the spleen

decreased T-helper 17 cell number ( J:160935 )

• in spleen and peyers patch

decreased IgA level ( J:160935 )

• barely detectable

decreased IgE level ( J:160935 )

• barely detectable

decreased IgG1 level ( J:160935 )

• barely detectable

decreased IgG2c level ( J:160935 )

• barely detectable

decreased IgM level ( J:160935 )

• modest reduction in circulating IgM

immune system

abnormal class switch recombination ( J:160935 )

• unlike control cells which when stimulated with LPS and IL-4 decreased IgM production and began IgG1, and IgE production, these cells continue to produce IgM

abnormal T-helper 2 cell differentiation ( J:160935 )

• when spenocytes are cultured under Th2 polarization conditions QPCR of Gata3 and Il4 show defects in polarization

absent germinal center B cells ( J:160935 )

• absent PNA+ cells

decreased CD4-positive, alpha-beta T cell number ( J:160935 )

• in spleen and peyers patch

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:160935 )

• small but significant reduction in Treg cells

decreased T follicular helper cell number ( J:160935 )

• memory-type CD62L-CXCR5+ Tfh cells are reduced by 70% in the spleen

decreased T-helper 17 cell number ( J:160935 )

• in spleen and peyers patch

decreased IgA level ( J:160935 )

• barely detectable

decreased IgE level ( J:160935 )

• barely detectable

decreased IgG1 level ( J:160935 )

• barely detectable

decreased IgG2c level ( J:160935 )

• barely detectable

decreased IgM level ( J:160935 )

• modest reduction in circulating IgM

decreased interleukin-17 secretion ( J:160935 )

• extremely low levels of IL17 in media from stimulated splenocytes

decreased interleukin-4 secretion ( J:160935 )

• in media from stimulated splenocytes