Phenotypes Associated with This Genotype

Genotype
MGI:4459317

• Allelic Composition: Esr1^tm1Sakh/Esr1^tm1Sakh; Tg(Wap-cre)11738Mam/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:124962 )

♀ • mosaic mammary gland phenotype in the first lactation

abnormal branching of the mammary ductal tree ( J:124962 )

♀ • mild defect in tertiary branching during first lactation

♀ • aberrantly dilated ducts with few side branches during second lactation

abnormal mammary gland alveolus morphology ( J:124962 )

♀ • some normal sized alveoli in first lactation

♀ • regions of reduced growth in the first lactation

♀ • fewer lobular alveoli during second lactation

abnormal lactation ( J:124962 )

♀ • one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days

♀ • more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days

♀ • normal milk quality

integument

abnormal mammary gland morphology ( J:124962 )

♀ • mosaic mammary gland phenotype in the first lactation

abnormal branching of the mammary ductal tree ( J:124962 )

♀ • mild defect in tertiary branching during first lactation

♀ • aberrantly dilated ducts with few side branches during second lactation

abnormal mammary gland alveolus morphology ( J:124962 )

♀ • some normal sized alveoli in first lactation

♀ • regions of reduced growth in the first lactation

♀ • fewer lobular alveoli during second lactation

abnormal lactation ( J:124962 )

♀ • one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days

♀ • more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days

♀ • normal milk quality