Phenotypes for Emx1 Pals1 MGI:4459295 MGI Mouse

mortality/aging ( J:160624 )

N	• mice exhibit normal survival

reproductive system phenotype ( J:160624 )

N	• mice exhibit normal reproduction

increased neuron apoptosis ( J:160624 )

• apoptosis in the cortex is increased beginning at E10.5 and peaks at E11 to E12 compared to in wild-type mice

• at E11 and E12, the number of postmitotic neurons is increased compared to in wild-type mice

• at E12, neuronal progenitor cells withdraw from the cell cycle 2.3-fold quicker than wild-type cells

• at E12 and E14, BrdU incorporation in neuronal progenitor cells is 2-fold less than in wild-type mice

• at E12.5 and E14.5, M-phase cell phospho-histone H3 labeling of neuronal progenitor cells is decreased compared to in wild-type mice

abnormal brain morphology ( J:160624 )

• mice exhibit fluid-filled cystic space contiguous with the lateral ventricle not observed in wild-type mice

• the cerebral cortex is virtually absent compared to in wild-type mice

• at E12 and E14, cortical size and morphology is abnormal compared to in wild-type mice

loss of cortex neurons ( J:160624 )

thin cerebral cortex ( J:160624 )

• in the lateral cortex

behavior/neurological phenotype ( J:160624 )

N	• mice exhibit normal reflexes and motor coordination

• initiation of exploration in an open field is decreased compared to wild-type mice

abnormal spatial learning ( J:160624 )

• mice fail to locate a visible platform in a Morris water maze unlike wild-type mice

abnormal placing response ( J:160624 )

• mice fail the visual forepaw reach test unlike wild-type mice

jerky movement ( J:160624 )

jumpy ( J:160624 )

decreased grip strength ( J:160624 )

• mice perform poorly in a wire hang test compared with wild-type mice

abnormal gait ( J:160624 )

• mice exhibit irregular and jumpy movements that disrupt their stride and gait unlike wild-type mice

decreased locomotor activity ( J:160624 )

• in an open field

decreased body weight ( J:160624 )

disheveled coat ( J:160624 )