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Phenotypes Associated with This Genotype
Genotype
MGI:4459095
Allelic
Composition
Tg(Mbp-Pad2)28Fgm/Tg(Mbp-Pad2)28Fgm
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no signs of immune cell infiltrates are detected (J:142650)
• no signs of immune cell infiltrates are detected (J:142650)
• develop convulsions by 1.5 months of age (J:142650)
• develop convulsions by 1.5 months of age (J:142650)
• thickened astrocytic processes are seen in the optic nerve (J:142650)
• thickened astrocytic processes are seen in the optic nerve (J:142650)
• optic nerves display areas of myelinolysis and thinly myelinated axons (J:142650)
• gene dosage correlated decrease in myelinated fiber density and myelin thickness (J:142650)
• however, no defects in myelin are detected in the peripheral nervous system (assayed in the sciatic nerve) (J:142650)
• optic nerves display areas of myelinolysis and thinly myelinated axons (J:142650)
• gene dosage correlated decrease in myelinated fiber density and myelin thickness (J:142650)
• however, no defects in myelin are detected in the peripheral nervous system (assayed in the sciatic nerve) (J:142650)
• show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age (J:142650)
• signs increase in severity with age more rapidly than in hemizygous mice (J:142650)
• decrease in myelination and irregular axonal staining in the brain (J:142650)
• myelin degradation, nude axons and thinly myelinated axons in the presence of myelinolysis are seen in the optic nerve (J:142650)
• show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age (J:142650)
• signs increase in severity with age more rapidly than in hemizygous mice (J:142650)
• decrease in myelination and irregular axonal staining in the brain (J:142650)
• myelin degradation, nude axons and thinly myelinated axons in the presence of myelinolysis are seen in the optic nerve (J:142650)

behavior/neurological
• develop tremors by 1.5 months of age (J:142650)
• develop tremors by 1.5 months of age (J:142650)
• display proprioceptive positioning defects at 4 months of age (J:142650)
• effects are more severe than in hemizygous mice (J:142650)
• display proprioceptive positioning defects at 4 months of age (J:142650)
• effects are more severe than in hemizygous mice (J:142650)
• becomes impaired by 1.5 months of age (J:142650)
• becomes impaired by 1.5 months of age (J:142650)
• at 4 months of age (J:142650)
• effects are more severe than in hemizygous mice (J:142650)
• at 4 months of age (J:142650)
• effects are more severe than in hemizygous mice (J:142650)
• at 4 months of age (J:142650)
• effects are more severe than in hemizygous mice (J:142650)
• at 4 months of age (J:142650)
• effects are more severe than in hemizygous mice (J:142650)
• hind end weakness is seen at 4 months of age (J:142650)
• hind end weakness is seen at 4 months of age (J:142650)
• develop tail droop by 1.5 months of age (J:142650)
• develop tail droop by 1.5 months of age (J:142650)
• develop a shaky gait by 1.5 months of age (J:142650)
• at 4 months of age the gait abnormality is more severe in the hind limbs (J:142650)
• develop a shaky gait by 1.5 months of age (J:142650)
• at 4 months of age the gait abnormality is more severe in the hind limbs (J:142650)
• develops by 1.5 months of age (J:142650)
• develops by 1.5 months of age (J:142650)
• develop convulsions by 1.5 months of age (J:142650)
• develop convulsions by 1.5 months of age (J:142650)

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:142650


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory