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Phenotypes Associated with This Genotype
Genotype
MGI:4458341
Allelic
Composition		 Ltbp4Gt(U3Cre)1Vmel/Ltbp4Gt(U3Cre)1Vmel
Sesn2Gt(W077E06)Wrst/Sesn2Gt(W077E06)Wrst
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbp4Gt(U3Cre)1Vmel mutation (1 available); any Ltbp4 mutation (140 available)
Sesn2Gt(W077E06)Wrst mutation (0 available); any Sesn2 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:160854 )
N
• unlike Ltbp4Gt(U3Cre)1Vmel homozygotes, lung compliance and elastin fiber morphology are not different from in wild-type mice
overexpanded pulmonary alveolus ( J:160854 )
• mice exhibit a less severe parenchymal lesions with decreased alveolar size and lung enlargement compared with Ltbp4Gt(U3Cre)1Vmel homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory