Phenotypes Associated with This Genotype

Genotype
MGI:4456427

• Allelic Composition: Apc^tm1.1Rsmi/Apc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

skin cyst ( J:159883 )

• very few cutaneous cysts are observed unlike in wild-type mice

mortality/aging

premature death ( J:159883 )

• primarily due to intestinal obstruction

neoplasm

increased gastrointestinal tumor incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased large intestine adenocarcinoma incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased small intestine adenocarcinoma incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased intestinal adenoma incidence ( J:159883 )

• polyp or flat adenoma

increased desmoid tumor incidence ( J:159883 )

• mice develop infrequent desmoid tumors

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased large intestine adenocarcinoma incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased small intestine adenocarcinoma incidence ( J:159883 )

• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice

increased intestinal adenoma incidence ( J:159883 )

• polyp or flat adenoma

intestinal obstruction ( J:159883 )

hematopoietic system

anemia ( J:159883 )

• severe

integument

skin cyst ( J:159883 )

• very few cutaneous cysts are observed unlike in wild-type mice