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Phenotypes Associated with This Genotype
Genotype
MGI:4456169
Allelic
Composition		 Gdnftm1.1Neas/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation (0 available); any Egr3 mutation (20 available)
Gdnftm1.1Neas mutation (1 available); any Gdnf mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
decreased motor neuron number ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
• mice exhibit a depletion in gamma-motor neurons at a similar time course as observed in Egr3tm1Jmi homozygotes

muscle
muscle phenotype ( J:160727 )
N
• mice exhibit normal muscle spindle morphology

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory