mortality/aging
N |
• normal lifespan
|
growth/size/body
• 13% reduction in birth weight, but by 8 weeks of age this weight difference is no longer observed
|
reproductive system
N |
• normal fertility
|
vision/eye
• the vitreal vessels remain endostatin positive throughout adulthood
|
• at 1 year of age eye diameters are 11% larger than those of controls
|
• ophthalmoscopy shows vitreal fibroplasia, vessel tortuosity, and retinal spots that are larger and more prominent than those in nmf223 homozygotes
|
• larger vessels lie within the vitreous and cover the entire retinal surface, and there is a lack of primary plexus veins and arteries within the retina
|
• intermediate and deep vascular plexi are present in the retina but not as dense as those of nmf223 homozygotes
|
• Muller cells lacking end-feet with misguided and shortened processes are found
|
• the inner limiting membrane does not form properly
|
• peripheral loss of cells in the inner plexiform and both nuclear layers of the retina, which is more severe and has an earlier onset than that in nmf223 homozygotes
|
retina spots
(
J:160722
)
cardiovascular system
• larger vessels lie within the vitreous and cover the entire retinal surface, and there is a lack of primary plexus veins and arteries within the retina
|
• intermediate and deep vascular plexi are present in the retina but not as dense as those of nmf223 homozygotes
|
nervous system
• Muller cells lacking end-feet with misguided and shortened processes are found
|