Phenotypes Associated with This Genotype

Genotype
MGI:4455335

• Allelic Composition: Igf1^tm1.1Dlr/Igf1^tm1.1Dlr; Tg(Ttr-IGF1)1Sykr/0
• Genetic Background: FVB.Cg-Igf1^tm1.1Dlr Tg(Ttr-IGF1)1Sykr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:157350 )

N • mice are born in normal Mendelian ratios

reproductive system

abnormal corpus luteum morphology ( J:157350 )

♀ • hypoplastic

abnormal mature ovarian follicle morphology ( J:157350 )

♀ • mice have few mature graafian follicles

ovary hypoplasia ( J:157350 )

♀

abnormal endometrium morphology ( J:157350 )

♀ • mice exhibit immature endometrial epithelium compared with wild-type mice

abnormal endometrial gland development ( J:157350 )

♀ • mice exhibit little glandular development compared with wild-type mice

decreased endometrial gland number ( J:157350 )

♀

endometrium hypoplasia ( J:157350 )

♀

myometrium hypoplasia ( J:157350 )

♀

increased superovulation rate ( J:157350 )

♀ • following hormone treatment, more eggs are released compared to in similarly treated wild-type mice

abnormal estrous cycle ( J:157350 )

♀ • irregular with prolonged diesterus and proesterus and shortened estrus

prolonged diestrus ( J:157350 )

♀

short estrus ( J:157350 )

♀

prolonged proestrus ( J:157350 )

♀

reduced female fertility ( J:157350 )

♀ • breeding of female mice is largely unsuccessful compared with wild-type mice

decreased litter size ( J:157350 )

• from female mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:157350 )

N • mice exhibit normal fasting glucose and glucose clearance

decreased circulating insulin level ( J:157350 )

• mice exhibit a tend towards reduced serum insulin levels compared with wild-type mice

abnormal insulin-like growth factor I level ( J:157350 )

• mice exhibit increased endocrine IGF-I levels compared with wild-type mice

increased circulating insulin-like growth factor I level ( J:157350 )

• 3-fold from 2 to 16 weeks of age

growth/size/body

decreased birth body size ( J:157350 )

• at birth, mice are smaller than wild-type mice

• however, body weight is normalized by 2 weeks of age

increased body length ( J:157350 )

• at 4 weeks of age, mice exhibit decreased body length compared with wild-type mice

• however, body length is normalized later on during growth and femur length is normal at 16 weeks of age

increased spleen weight ( J:157350 )

adipose tissue

decreased total body fat amount ( J:157350 )

• at 4 but not 8 weeks

decreased gonadal fat pad weight ( J:157350 )

decreased percent body fat/body weight ( J:157350 )

• at 4 and 8 weeks but not 16 weeks

hematopoietic system

increased spleen weight ( J:157350 )

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:157350 )

♀ • mice exhibit increased ductal branching compared to in wild-type mice

abnormal endometrial gland development ( J:157350 )

♀ • mice exhibit little glandular development compared with wild-type mice

decreased endometrial gland number ( J:157350 )

♀

abnormal corpus luteum morphology ( J:157350 )

♀ • hypoplastic

abnormal mature ovarian follicle morphology ( J:157350 )

♀ • mice have few mature graafian follicles

ovary hypoplasia ( J:157350 )

♀

immune system

increased spleen weight ( J:157350 )

integument

abnormal branching of the mammary ductal tree ( J:157350 )

♀ • mice exhibit increased ductal branching compared to in wild-type mice