Phenotypes Associated with This Genotype

Genotype
MGI:4455334

• Allelic Composition: Tg(Ttr-IGF1)1Sykr/0
• Genetic Background: FVB/N-Tg(Ttr-IGF1)1Sykr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:157350 )

N • mice exhibit normal fasting glucose and glucose clearance

decreased circulating insulin level ( J:157350 )

• mice exhibit a tend towards reduced serum insulin levels compared with wild-type mice

increased circulating insulin-like growth factor I level ( J:157350 )

adipose tissue

decreased total body fat amount ( J:157350 )

• at 4 ad 8 weeks in female mice

decreased gonadal fat pad weight ( J:157350 )

decreased percent body fat/body weight ( J:157350 )

• at 4 and 8 weeks but not 16 weeks

reproductive system

increased superovulation rate ( J:157350 )

♀ • following hormone treatment, more eggs are released compared to in similarly treated wild-type mice

growth/size/body

increased body weight ( J:157350 )

• starting at 2 weeks and persistent throughout 16 weeks

increased body length ( J:157350 )

• at 4 weeks of age

increased kidney weight ( J:157350 )

• 25% to 35%

increased liver weight ( J:157350 )

• 25% to 35%

increased spleen weight ( J:157350 )

• 25% to 35%

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:157350 )

♀ • mice exhibit increased ductal branching compared to in wild-type mice

hematopoietic system

increased spleen weight ( J:157350 )

• 25% to 35%

renal/urinary system

increased kidney weight ( J:157350 )

• 25% to 35%

liver/biliary system

increased liver weight ( J:157350 )

• 25% to 35%

immune system

increased spleen weight ( J:157350 )

• 25% to 35%

integument

abnormal branching of the mammary ductal tree ( J:157350 )

♀ • mice exhibit increased ductal branching compared to in wild-type mice