Phenotypes Associated with This Genotype

Genotype
MGI:4455317

• Allelic Composition: Megf8^m687Ddg/Megf8^m687Ddg
• Genetic Background: involves: C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:159834 )

• mice exhibit abnormal development and patterning of the peripheral nervous system compared with wild-type mice

abnormal axon fasciculation ( J:159834 , J:206541 )

• mice exhibit defasciculation of the ophthalmic branch of the trigeminal ganglia compared with wild-type mice (J:159834)

• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face (J:206541)

abnormal trigeminal nerve morphology ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face

• however, the maxillary and mandibular branches are largely unaffected

abnormal ophthalmic nerve morphology ( J:159834 , J:206541 )

• mice exhibit defasciculation of the ophthalmic branch of the trigeminal ganglia compared with wild-type mice (J:159834)

• axons within defasciculated bundles occupy a loosely defined tract and spread out prematurely within the face unlike in wild-type mice (J:159834)

• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face (J:206541)

abnormal spinal nerve morphology ( J:159834 )

• underdeveloped

cellular

abnormal axon fasciculation ( J:159834 , J:206541 )

• mice exhibit defasciculation of the ophthalmic branch of the trigeminal ganglia compared with wild-type mice (J:159834)

• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face (J:206541)