Megf8^m687Ddg
Chemically induced Allele Detail

Summary

• Symbol: Megf8^m687Ddg
• Name: multiple EGF-like-domains 8; mutation 687, David D Ginty
• MGI ID: MGI:4455205
• Synonyms: Megf8^L1775P
• Gene: Megf8 Location: Chr7:25016589-25065342 bp, + strand Genetic Position: Chr7, 13.75 cM
• Alliance: Megf8^m687Ddg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C point mutation that results in the amino acid substitution of proline for lysine at position 1775 (L1775P) in the fourth Kelch domain. (J:206541)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Megf8 Mutation: 96 strains or lines available

References

• Original: J:159834 Merte J, et al., A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. J Neurosci. 2010 Apr 21;30(16):5767-75
• All: 2 reference(s)