About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4455026
Allelic
Composition
RhoTvrm1/Rho+
Genetic
Background
C57BL/6J-RhoTvrm1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm1 mutation (1 available); any Rho mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Photoreceptor degeneration in RhoTvrm4/Rho+ and RhoTvrm1/Rho+ mutants is rapidly induced by exposure to bright light

vision/eye
• exposure to 12,000 lux of light for only 30 s results in degeneration in 4 of 6 mice
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 30 or more seconds induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected
• mice recover more slowly, with a time constant of 11.5 min and reach an asymptote that falls short of the dark adapted value

homeostasis/metabolism
• in extracts of whole eyes collected immediately after exposure to 12,000 lux for 5 mins a trend is seen toward lower levels of all trans-retinols than in wild-type
• however, no difference is detected at 1 h after light exposure
• exposure to 12,000 lux of light for only 30 s results in degeneration in 4 of 6 mice

nervous system
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 30 or more seconds induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:159523


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/31/2020
MGI 6.15
The Jackson Laboratory