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Phenotypes Associated with This Genotype
Genotype
MGI:4454658
Allelic
Composition		 Foxn1nu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (106 available)
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (106 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased thymocyte apoptosis ( J:159773 )
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
abnormal thymus epithelium morphology ( J:159773 )
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

hematopoietic system
increased thymocyte apoptosis ( J:159773 )
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
abnormal thymus epithelium morphology ( J:159773 )
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

cellular
increased thymocyte apoptosis ( J:159773 )
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice

endocrine/exocrine glands
increased thymocyte apoptosis ( J:159773 )
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
abnormal thymus epithelium morphology ( J:159773 )
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory