Phenotypes for a Oca2 MGI:4454423 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	a/a Oca2^p-J/Oca2^p-J
Genetic Background	involves: C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (166 available); any a mutation (468 available)
Oca2^p-J mutation (4 available); any Oca2 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanosome morphology ( J:5346 )

• reorganization of fibrillar melanosomes into particulate melanin granules, such that only 20% of melanosomes in adult retina are fibrillar in nature, the rest are particulate

abnormal choroid melanin granule morphology ( J:5346 )

• 2% of premelanosomes in the choroid are fused to form giant granules

abnormal melanogenesis ( J:5346 )

• premature termination of melanization of the premelanosome filaments in the retina

vision/eye

abnormal choroid melanin granule morphology ( J:5346 )

• 2% of premelanosomes in the choroid are fused to form giant granules

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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