Analysis Tools
nervous system
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• sympathetic ganglia are significantly smaller and have reduced cell numbers at E11.5
but, by E18.5 ganglia are almost the same size as in wild-type controls and cell numbers are normalized
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• expression analysis indicates a transient delay in noradrenergic differentiation in the sympathetic ganglia
• sympathetic ganglia are almost devoid of proliferating cells at E11.5 and have a dramatic reduction at E12.5 but by E14.5 the absolute number of BrdU-labeled cells is only slightly lower than in the wild-type
when corrected for the decrease in size of the sympathetic ganglia, proliferation is increased relative to wild-type at E14.5 and E16.5
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