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Phenotypes Associated with This Genotype
Genotype
MGI:4454328
Allelic
Composition		 Cd226tm1.1Cln/Cd226tm1.1Cln
Tg(TcraTcrb)1100Mjb/0
Genetic
Background		 B6.Cg-Cd226tm1.1Cln Tg(TcraTcrb)1100Mjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd226tm1.1Cln mutation (0 available); any Cd226 mutation (32 available)
Tg(TcraTcrb)1100Mjb mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased cytotoxic T cell cytolysis ( J:159749 )
• CD8 T cells kill B16 cells pulsed with OVA peptide 257-264 less effectively than control CD8 T cells
abnormal T cell activation ( J:159749 )
• CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with Pvr and pulsed with OVA peptide 257-264 fail to become activated
decreased T cell proliferation ( J:159749 )
• in CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with murine Pvr and pulsed with OVA peptide 257 ? 264
• however, proliferation in response to dendritic cell stimulation is similar to wild-type

immune system
decreased cytotoxic T cell cytolysis ( J:159749 )
• CD8 T cells kill B16 cells pulsed with OVA peptide 257-264 less effectively than control CD8 T cells
abnormal T cell activation ( J:159749 )
• CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with Pvr and pulsed with OVA peptide 257-264 fail to become activated
decreased T cell proliferation ( J:159749 )
• in CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with murine Pvr and pulsed with OVA peptide 257 ? 264
• however, proliferation in response to dendritic cell stimulation is similar to wild-type
decreased interferon-gamma secretion ( J:159749 )
• fewer IFN gamma secreting T cells are evident in lymph nodes after restimulation with the T cell lymphoma cell line EL-4 cells transfected with Pvr and pulsed with OVA peptide 257-264
• however, the frequency of IFN gamma secreting cells is similar to wild-type after restimulation with dendritic cells

cellular
decreased T cell proliferation ( J:159749 )
• in CD8 T cells stimulated with T cell lymphoma cell line EL-4 transfected with murine Pvr and pulsed with OVA peptide 257 ? 264
• however, proliferation in response to dendritic cell stimulation is similar to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory