Phenotypes Associated with This Genotype

Genotype
MGI:4453964

• Allelic Composition: Hand2^tm1.2Zllr/Hand2^tm1.2Zllr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

embryonic growth retardation ( J:159210 )

• growth retardation at E9.5-9.75 (25-27 somites)

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:159210 )

• malformed branchial arches at embryonic day E9.5-9.75

dilated aortic sac ( J:159210 )

• dilated aortic sac at E9.5-9.75

distended pericardium ( J:159210 )

• dilated pericardial sac at E9.5-9.75

cellular

increased embryonic tissue cell apoptosis ( J:159210 )

• massive and generalized cell death in embryos and limb buds at E9.5

craniofacial

abnormal pharyngeal arch artery morphology ( J:159210 )

• malformed branchial arches at embryonic day E9.5-9.75

embryo

abnormal pharyngeal arch artery morphology ( J:159210 )

• malformed branchial arches at embryonic day E9.5-9.75

increased embryonic tissue cell apoptosis ( J:159210 )

• massive and generalized cell death in embryos and limb buds at E9.5

embryonic growth retardation ( J:159210 )

• growth retardation at E9.5-9.75 (25-27 somites)